A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
نویسندگان
چکیده
منابع مشابه
A human leucyl-tRNA synthetase as an anticancer target
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The target of rapamycin complex 1 (TORC1) is an essential regulator of eukaryotic cell growth that responds to growth factors, energy levels, and amino acids. The mechanisms through which the preeminent amino acid leucine signals to the TORC1-regulatory Rag GTPases, which activate TORC1 within the yeast EGO complex (EGOC) or the structurally related mammalian Rag-Ragulator complex, remain elusi...
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Human cytosolic leucyl-tRNA synthetase is one component of a macromolecular aminoacyl-tRNA synthetase complex. This is unlike prokaryotic and lower eukaryotic LeuRSs that exist as free soluble enzymes. There is little known about it, since the purified enzyme has been unavailable. Herein, human cytosolic leucyl-tRNA synthetase was heterologously expressed in a baculovirus system and purified to...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2021
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02420-20